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Alkylating Agents

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1

Describe the MOA for alkylating agents?

breaks the DNA helix strand, thereby interfering w/DNA replication.

2

List alkylating agents.

1. Altretamine (Hexalene)
2. Bendamustine (Treanda)
3. Busulfan (Myleran <po>, Busulfex <IV>)
4. Carboplatin (Paraplatin)
5. Chlorambucil (Leukeran)
6. Cisplatin (Platinol)
7. Cyclophosphamide (Cytoxan)
8. Dacarbazine (DTIC)
9. Ifosfamide (Ifex)
10. Mechlorethamine (nitrogen mustard, Mustargen)
11. Mephalan (Alkeran)
12. Oxaliplatin (Eloxatin)
13. Temozolomide (Temodar)
14. Thiotepa (Thioplex)

3

List the alkylating agents that are used in ovarian cancer.

Altretamine (Hexalene)
Carboplatin (Paraplatin)
Cisplatin (Patinol)
Cyclophosphamide (Cytoxan)
Mephalan (Alkeran)
Thiotepa (Thioplex)

4

List the alkylating agent(s) that are used in CLL.

Bendamustine (Treanda)
Chlorambucil (Leukeran)
Cisplatin (Paraplatin) "used in leukemias"
Cyclophosphamide (Cytoxan) "used in leukemias"
Mechlorethamine (nitrogen mustard, Mustargen)

5

List the alkylating agents used in B-cell NHL or NHL.

Bendamustine (Treanda) "B-cell NHL"
Chlorambucil (Leukeran) "NHL"
Cyclophosphamide (Cytoxan) "lymphomas"
Ifosfamide (Ifex) "NHL"
Mechlorethamine (nitrogen mustard, Mustargen) "NHL"
Thiotepa (Thioplex) "NHL;lymphomas"


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